Electrical stimulation effects on cell cycle and autophagy markers in MCF7 and MDA-MB-468 breast cancer cells

Simple item page
dc.contributor.advisorConnor, Michael K.
dc.contributor.authorHabib, Ramy
dc.date.accessioned2022-12-14T16:43:56Z
dc.date.available2022-12-14T16:43:56Z
dc.date.copyright2022-09-22
dc.date.issued2022-12-14
dc.date.updated2022-12-14T16:43:56Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractBreast cancer is a major health problem commonly seen in women. Despite considerable advancements in cancer research, cancer incidence continues to increase and cancer remains the second cause of death globally. It is crucial to further improve current cancer therapies and investigate novel treatments. This study evaluates the effects of electrical pulse stimulation (EPS) on breast cancer cells. This is based on previous work on myoblasts, cancerous rhabdomyosarcoma cells, and MCF7 breast cancer cells. EPS of MCF7 and MDA-MB-468 breast cancer cells revealed alterations in cellular signaling that suggest cell cycle arrest by autophagy. An Akt inhibitor was used to identify the role of Akt in the EPS response on breast cancer cells. This adds to a working model of cell cycle arrest by autophagy on cancer cells subject to EPS, and is a promising novel therapy that can be used to induce intrinsic cellular arrest mechanisms in cancer cells.
dc.identifier.urihttp://hdl.handle.net/10315/40790
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectKinesiology
dc.subject.keywordsBreast cancer
dc.subject.keywordsmcf7
dc.subject.keywordsMDA
dc.subject.keywordsCancer
dc.subject.keywordsBreast
dc.subject.keywordsEPS
dc.subject.keywordsElectrical stimulation
dc.subject.keywordsElectrical pulse stimulation
dc.subject.keywordsAutophagy
dc.subject.keywordsCell cycle
dc.subject.keywordsCancer therapy
dc.titleElectrical stimulation effects on cell cycle and autophagy markers in MCF7 and MDA-MB-468 breast cancer cells
dc.typeElectronic Thesis or Dissertation

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Habib_Ramy_2022_MSc.pdf
Size:
1.56 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
license.txt
Size:
1.87 KB
Format:
Plain Text
Description:
Download
No Thumbnail Available
Name:
YorkU_ETDlicense.txt
Size:
3.39 KB
Format:
Plain Text
Description:
Download

Collections

Kinesiology & Health Science

All items in the YorkSpace institutional repository are protected by copyright, with all rights reserved except where explicitly noted.