Synthesis of Carbamoyl Fluorides Using a Difluorophosgene Surrogate Derived from Difluorocarbene and Pyridine N-Oxides
| dc.contributor.author | Cadwallader, Dusty | |
| dc.contributor.author | Tiburcio, Tristan R. | |
| dc.contributor.author | Cieszynski, George A. | |
| dc.contributor.author | Le, Christine M. | |
| dc.date.accessioned | 2023-06-02T16:08:37Z | |
| dc.date.available | 2023-06-02T16:08:37Z | |
| dc.date.issued | 2022-08-16 | |
| dc.description.abstract | We report a method for the synthesis of carbamoyl fluorides from secondary amines using bench-stable, inexpensive, and readily accessible starting materials that, when combined, yield a surrogate for toxic difluorophosgene (COF2) gas. In contrast to state-of-the-art methods for the synthesis of carbamoyl fluorides, our protocol does not require the use of pre-functionalized substrates, the preparation of light-, temperature-, and/or moisture-sensitive chemicals, or the application of explosive fluorinating reagents. | en_US |
| dc.identifier.citation | J. Org. Chem. 2022, 87, 17, 11457–11468 | en_US |
| dc.identifier.uri | 10.1021/acs.joc.2c01017 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10315/41192 | |
| dc.language.iso | en | en_US |
| dc.publisher | American Chemical Society | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
| dc.subject | difluorocarbene, carbamoyl fluorides, fluorination | en_US |
| dc.title | Synthesis of Carbamoyl Fluorides Using a Difluorophosgene Surrogate Derived from Difluorocarbene and Pyridine N-Oxides | en_US |
| dc.type | Article | en_US |