Does Epigenetic Silencing Affect Skeletal Muscle Angiogenesis?

Simple item page
dc.contributor.advisorRoudier, Emilie
dc.contributor.authorAkhtar, Sokaina
dc.date.accessioned2023-03-28T21:21:57Z
dc.date.available2023-03-28T21:21:57Z
dc.date.copyright2022-12-16
dc.date.issued2023-03-28
dc.date.updated2023-03-28T21:21:57Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractThe skeletal muscle is a highly plastic tissue that is able to adapt to changes from different stressors such as exercise. Angiogenesis is the formation of new capillaries from existing vessels; allowing for better blood flow to the working skeletal muscles. Epigenetic modifications support changes in gene expression to allow for skeletal muscle adaptations. How histone silencing marks regulate skeletal muscle adaptations through angiogenesis in response to training is yet to be explored in depth. My thesis aims to research how histone silencing marks regulate skeletal muscle angiogenesis through MDM2 and EZH2, in the context of exercise. In C57BL6 female mice, 9 weeks of endurance training increased H3K27me3 protein global abundance. With an acute bout of exercise in 14 days trained, H3K27me3 decreased. Angiogenic gene Kdr mRNA expression decreased after 9 weeks of endurance training. Overall, exercise protocols affect the histone modifications and histone modifiers in the skeletal muscle.
dc.identifier.urihttp://hdl.handle.net/10315/41027
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectKinesiology
dc.subject.keywordsEpigenetics
dc.subject.keywordsSkeletal muscle angiogenesis
dc.subject.keywordsMDM2
dc.subject.keywordsEZH2
dc.subject.keywordsH3K27me3
dc.subject.keywordsHistone silencing
dc.subject.keywordsEndurance exercise
dc.subject.keywordsAngio-adaptation
dc.titleDoes Epigenetic Silencing Affect Skeletal Muscle Angiogenesis?
dc.typeElectronic Thesis or Dissertation

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Akhtar_Sokaina_2022_Masters.pdf
Size:
2.38 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
license.txt
Size:
1.87 KB
Format:
Plain Text
Description:
Download
No Thumbnail Available
Name:
YorkU_ETDlicense.txt
Size:
3.39 KB
Format:
Plain Text
Description:
Download

Collections

Kinesiology & Health Science

All items in the YorkSpace institutional repository are protected by copyright, with all rights reserved except where explicitly noted.