Do nuclear envelope and intranuclear proteins reorganize during mitosis to form an elastic, hydrogel-like spindle matrix?

dc.contributor.authorJohansen, Kristen
dc.contributor.authorForer, Arthur
dc.contributor.authorYao, Changfu
dc.contributor.authorGirton, Jack
dc.contributor.authorJohansen, Jørgen
dc.date.accessioned2021-03-01T17:03:24Z
dc.date.available2021-03-01T17:03:24Z
dc.date.issued2011-01
dc.description.abstractThe idea of a spindle matrix has long been proposed in order to account for poorly understood features of mitosis. However, its molecular nature and structural composition have remained elusive. Here we propose that the spindle matrix may be constituted by mainly nuclear-derived proteins that reorganize during the cell cycle to form an elastic gel-like matrix. We discuss this hypothesis in the context of recent observations from phylogenetically diverse organisms that nuclear envelope and intranuclear proteins form a highly dynamic and malleable structure that contributes to mitotic spindle function. We suggest that the visco-elastic properties of such a matrix may constrain spindle length while at the same time facilitating microtubule growth and dynamics as well as chromosome movement. A corollary to this hypothesis is that a key determinant of spindle size may be the amount of nuclear proteins available to form the spindle matrix. Such a matrix could also serve as a spatial regulator of spindle assembly checkpoint proteins during open and semi-open mitosis.en_US
dc.identifier.citationChromosome Research volume 19, pages345–365(2011)en_US
dc.identifier.issn0967-3849
dc.identifier.urihttps://doi.org/10.1007/s10577-011-9187-6en_US
dc.identifier.urihttp://hdl.handle.net/10315/38122
dc.language.isoenen_US
dc.publisherSpringer Linken_US
dc.rightsSpringer This is a post-peer-review, pre-copyedit version of an article published in Chromosome Research. The final authenticated version is available online at: https://doi.org/10.1007/s10577-011-9187-6. More information on Springer Nature terms of reuse for archived author accepted manuscripts (AAMs) of subscription articles can be found at https://www.springer.com/gp/open-access/publication-policies/aam-terms-of-use.en_US
dc.rightsAttribution-NoDerivatives 4.0 International*
dc.rights.articlehttps://link.springer.com/article/10.1007%2Fs10577-011-9187-6en_US
dc.rights.journalhttps://www.springer.com/journal/10577en_US
dc.rights.publisherhttps://link.springer.com/en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/*
dc.subjectspindle matrixen_US
dc.subjectmitosisen_US
dc.subjectnuclear envelopeen_US
dc.subjectnucleoporinsen_US
dc.subjectmicrotubulesen_US
dc.subjectnuclear reorganizationen_US
dc.titleDo nuclear envelope and intranuclear proteins reorganize during mitosis to form an elastic, hydrogel-like spindle matrix?en_US
dc.title.alternativeShort title: The spindle matrixen_US
dc.typeArticleen_US

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