Proline/Alanine Tails as Ionization Enhancement Tags in Native Mass Spectrometry
| dc.contributor.author | Abdalla, Marwa | |
| dc.contributor.author | Lento, Cristina | |
| dc.contributor.author | Jiang, Guifeng | |
| dc.contributor.author | Power, Austin | |
| dc.contributor.author | Wilson, Derek | |
| dc.date.accessioned | 2023-06-08T19:43:17Z | |
| dc.date.available | 2023-06-08T19:43:17Z | |
| dc.date.issued | 2023-05-12 | |
| dc.description.abstract | This study aimed to study the impact of Proline/Alanine tag on l-asparaginase protein dynamics. Our current analysis demonstrates that the PA tail fragment did not change the core protein dynamics using TRESI HDX MS to provide identical stability with untagged l-asparaginase. Novel Aspects In this work, we propose PASylation ® as a new tool for ionization enhancement through chain ejection. | en_US |
| dc.description.sponsorship | Funding for this work was provided by the Natural Sciences and Engineering Research Council of Canada (NSERC) CRD program. Mitacs program grant collaboration between York University and Jazz Pharmaceuticals. Funded by: funder-id http://dx.doi.org/10.13039/501100000038, Natural Sciences and Engineering Research Council of Canada; Award ID: RGPIN 480432 Funded by: funder-id http://dx.doi.org/10.13039/501100004489, Mitacs; | en_US |
| dc.identifier.citation | Marwa ElSabaawy, Cristina Lento and Guifeng Jiang et al. Proline/Alanine Tails as Ionization Enhancement Tags in Native Mass Spectrometry. ScienceOpen Posters. 2023. DOI: 10.14293/P2199-8442.1.SOP-.PYK0FB.v1 | en_US |
| dc.identifier.uri | https://doi.org/10.14293/P2199-8442.1.SOP-.PYK0FB.v1 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10315/41196 | |
| dc.language.iso | en | en_US |
| dc.title | Proline/Alanine Tails as Ionization Enhancement Tags in Native Mass Spectrometry | en_US |
| dc.type | Poster | en_US |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- AAM.10.14293.P2199-8442.1.SOP-.PYK0FB.v1.pdf
- Size:
- 2.18 MB
- Format:
- Adobe Portable Document Format
- Description:
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.83 KB
- Format:
- Item-specific license agreed upon to submission
- Description: