Tricyclic and SSRI Usage Influences the Association Between BMI and Health Risk Factors

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dc.contributor.advisorKuk, Jennifer
dc.creatorCarlton, Kristin Jennifer
dc.date.accessioned2015-01-26T14:37:46Z
dc.date.available2015-01-26T14:37:46Z
dc.date.copyright2014-07-08
dc.date.issued2015-01-26
dc.date.updated2015-01-26T14:37:46Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractThe prevalence of antidepressant use is increasing. Past studies have reported that the use of antidepressants can influence cardiovascular risk factors including obesity, blood lipids and blood pressure (BP). However, because antidepressants have the potential to influence both body weight and cardiovascular disease (CVD) risk, it is currently unclear if antidepressant use alters CVD risk independent of obesity. Therefore, the aim of this manuscript was to examine if the type of antidepressant (Selective-Serotonin Reuptake Inhibitors (SSRIs) or Tricyclic antidepressants (TCAs)) used influenced the association between obesity and CVD risk. This study demonstrated that for a given body mass index (BMI) certain antidepressant use was associated with exacerbated health risk factors and CVD risk. Clinically, this may indicate that the differences in body weight observed with the use of SSRIs and TCAs may not be associated with the normally expected differences in cardiovascular risk.
dc.identifier.urihttp://hdl.handle.net/10315/28215
dc.language.isoen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectKinesiology
dc.subjectHealth sciences
dc.subjectEpidemiology
dc.subject.keywordsHomeostatic Model Assessment of Insulin Resistance (HOMA-IR)en_US
dc.subject.keywordsAntidepressantsen_US
dc.subject.keywordsMedicationsen_US
dc.subject.keywordsTricyclic antidepressants (TCA)en_US
dc.subject.keywordsSelective-Serotonin Reuptake Inhibitors (SSRIs)en_US
dc.subject.keywordsMental healthen_US
dc.subject.keywordsDepressionen_US
dc.subject.keywordsMood disordersen_US
dc.subject.keywordsBody mass index (BMI)en_US
dc.subject.keywordsCardiovascular disease (CVD)en_US
dc.subject.keywordsDiabetesen_US
dc.subject.keywordsCardiometabolicen_US
dc.subject.keywordsHealth risk factorsen_US
dc.subject.keywordsNational Health and Nutrition Examination Survey (NHANES)en_US
dc.subject.keywordsCenters for Disease Control and Prevention (CDC)en_US
dc.subject.keywordsSystolic blood pressure (SBP)en_US
dc.subject.keywordsDiastolic blood pressure (DBP)en_US
dc.subject.keywordsHigh-density liprotein (HDL)en_US
dc.subject.keywordsTriglycerides (TGs)en_US
dc.subject.keywordsFasting plasma glucose (FPG)en_US
dc.subject.keywordsGlycohemoglobin (HbA1c)en_US
dc.subject.keywordsInsulinen_US
dc.titleTricyclic and SSRI Usage Influences the Association Between BMI and Health Risk Factors
dc.typeElectronic Thesis or Dissertation

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