A randomised, controlled study of peri-operative low dose s(+)-ketamine in combination with postoperative patient-controlled s(+)-ketamine and morphine after radical prostatectomy
| dc.contributor.author | Snijdelaar, Dirk G. | |
| dc.contributor.author | Cornelisse, H.B. | |
| dc.contributor.author | Schmid, R. L. | |
| dc.contributor.author | Katz, Joel | |
| dc.date.accessioned | 2011-05-18T20:12:34Z | |
| dc.date.available | 2011-05-18T20:12:34Z | |
| dc.date.issued | 2004 | |
| dc.description.abstract | In a randomised, double-blind prospective study we compared the effects on postoperative pain and analgesic consumption of intra-operative s(+)-ketamine (100 μg.kg−1 bolus and a continuous infusion of 2 μg.kg−1.min−1) followed by postoperative patient-controlled analgesia with morphine (1 mg per bolus) plus s(+)-ketamine (0.5 mg per bolus), or intra-operative saline followed by postoperative patient-controlled analgesia morphine (1 mg per bolus) alone. A total of 28 male patients undergoing radical prostatectomy were studied. Morphine consumption, pain scores, pressure algometry and adverse effects were recorded for 48 h after surgery. Cumulative morphine consumption was significantly lower in the ketamine/morphine group (47.9 ± 26.2 mg) than in the saline/morphine group (73.4 ± 34.8 mg; p = 0.049). Pain scores at rest were significantly lower in the ketamine/morphine group across the 48-h study period (p = 0.01). No significant differences were found in pressure algometry measurements or the occurrence of adverse effects. | en |
| dc.identifier.citation | Anaesthesia, 59(3), 222-228. (2004) | |
| dc.identifier.uri | http://hdl.handle.net/10315/7962 | |
| dc.language.iso | en | en |
| dc.publisher | Lippincott, Williams and Wilkins | en |
| dc.rights.article | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2044.2003.03620.x/pdf | |
| dc.rights.journal | http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2044 | en |
| dc.rights.publisher | http://www.lww.com/ | en |
| dc.title | A randomised, controlled study of peri-operative low dose s(+)-ketamine in combination with postoperative patient-controlled s(+)-ketamine and morphine after radical prostatectomy | |
| dc.type | Article | en |