The Stability of a Ketamine-Morphine Solution
| dc.contributor.author | Schmid, Roger | |
| dc.contributor.author | Koren, Gideon | |
| dc.contributor.author | Klein, Julia | |
| dc.contributor.author | Katz, Joel | |
| dc.date.accessioned | 2011-05-18T19:52:17Z | |
| dc.date.available | 2011-05-18T19:52:17Z | |
| dc.date.issued | 2002 | |
| dc.description.abstract | Recent advances in acute pain mechanisms and management have implicated the N-methyl D-aspartate receptor-ion channel complex in the development of postoperative hyperalgesia and acute opioid tolerance. N-methyl D-aspartate receptor antagonists such as ketamine have been used increasingly in clinical studies in an effort to minimize acute postoperative pain and reduce opioid requirements. A mixture of ketamine and an opioid administered in the same solution and syringe would be a practical and useful technique for postoperative epidural analgesia, continuous IV infusion, or patient-controlled IV analgesia. We investigated the stability of a morphine sulfate and racemic ketamine solution in saline at pH 5.5–7.5 over a period of 4 days. Our study demonstrates that the ketamine-morphine mixture at a clinically relevant concentration seems to be stable at room temperature, at a wide range of pH values, for at least 4 days. | en |
| dc.identifier.citation | Anesthesia & Analgesia, 94(4), 898-900. (2002) | |
| dc.identifier.uri | http://hdl.handle.net/10315/7954 | |
| dc.language.iso | en | en |
| dc.publisher | Lippincott, Williams and Wilkins | en |
| dc.rights.article | http://www.anesthesia-analgesia.org/content/94/4/898.full.pdf+html | |
| dc.rights.journal | http://www.anesthesia-analgesia.org/ | en |
| dc.rights.publisher | http://www.lww.com/ | en |
| dc.title | The Stability of a Ketamine-Morphine Solution | |
| dc.type | Article | en |