Sex Differences in Skeletal Muscle Endothelial Cells

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dc.contributor.advisorHaas, Tara
dc.contributor.authorGarland, Elizabeth Jane
dc.date.accessioned2022-12-14T16:43:17Z
dc.date.available2022-12-14T16:43:17Z
dc.date.copyright2022-09-28
dc.date.issued2022-12-14
dc.date.updated2022-12-14T16:43:16Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractThe proper functioning of endothelial cells (ECs) is often impaired during obesity-related disorders. Our lab’s previous data demonstrated sex differences in mitochondrial functioning and angiogenic capacity in adipose microvascular ECs. The goal of this study was to identify potential sex differences in lipid handling and metabolic capacities of skeletal muscle ECs. To achieve this, ECs were isolated from hindlimb skeletal muscle of mice and treated in culture to mimic obesogenic-like conditions. I found higher proliferation and lipid storage in female ECs in control conditions. In control and obesogenic-like conditions, females expressed higher levels of lipid handling genes, while males displayed greater Hk2 expression. Obesogenic-like conditions resulted in increased expression of Pfkfb3 in females, and decreased insulin sensitivity in male ECs only. These data provide evidence of sex-related differences in skeletal muscle ECs which can help to identify how their response to altered nutrient environment may in turn affect tissue health.
dc.identifier.urihttp://hdl.handle.net/10315/40784
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectCellular biology
dc.subjectKinesiology
dc.subjectHealth sciences
dc.subject.keywordsSkeletal muscle
dc.subject.keywordsMicrovascular
dc.subject.keywordsSex dimorphism
dc.subject.keywordsFatty acid transport
dc.subject.keywordsGlucose transport
dc.subject.keywordsMetabolism
dc.titleSex Differences in Skeletal Muscle Endothelial Cells
dc.typeElectronic Thesis or Dissertation

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