Elastic ‘tethers’ connect separating anaphase chromosomes in a broad range of animal cells.

dc.contributor.authorForer, Arthur
dc.contributor.authorDuquette, Michelle L.
dc.contributor.authorPaliulis, Leocadia V.
dc.contributor.authorFegaras, E.
dc.contributor.authorOno, M.
dc.contributor.authorPreece, D.
dc.contributor.authorBerns, Michael
dc.date.accessioned2021-03-01T18:33:08Z
dc.date.available2021-03-01T18:33:08Z
dc.date.issued2017-09
dc.description.abstractWe describe the general occurrence in animal cells of elastic components (“tethers”) that connect individual chromosomes moving to opposite poles during anaphase. Tethers, originally described in crane-fly spermatocytes, produce force on chromosome arms opposite to the direction the anaphase chromosomes move. In crane-fly spermatocytes tethers function to coordinate movements between chromosomes. Their presence in a broad range of cells suggests that they may be important in coordinating movements between chromosomes to ensure normal segregation. Tethers are previously unrecognised force-producing components of general mitotic mechanisms and need to be accounted for in general models of mitosis in terms of forces on chromosomes and in terms of what their roles might be, possibly in coordinating chromosome movements during mitosis.en_US
dc.identifier.citationEuropean Journal of Cell Biology 96.6 (2017): 504-514en_US
dc.identifier.issn0171-9335
dc.identifier.urihttps://doi.org/10.1016/j.ejcb.2017.07.001en_US
dc.identifier.urihttp://hdl.handle.net/10315/38125
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsElsevier Journals © <2017>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.rightsAttribution-NoDerivatives 4.0 International*
dc.rights.articlehttps://www.sciencedirect.com/science/article/abs/pii/S017193351730136X#!en_US
dc.rights.journalhttps://www.sciencedirect.com/journal/european-journal-of-cell-biologyen_US
dc.rights.publisherhttps://www.sciencedirect.com/en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/*
dc.subjectspindle structureen_US
dc.subjectchromosome tethersen_US
dc.subjectanaphaseen_US
dc.subjectlaser microbeamen_US
dc.subjectchromosomesen_US
dc.titleElastic ‘tethers’ connect separating anaphase chromosomes in a broad range of animal cells.en_US
dc.title.alternativeRunning Head: Backward forces on anaphase chromosomesen_US
dc.typeArticleen_US

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