Forer, Arthur2021-03-012021-03-012013-01Cell Biology International 33.2 (2009): 253-253.1095-8355https://doi.org/10.1016/j.cellbi.2008.11.004http://hdl.handle.net/10315/38123Several articles in a recent issue of this journal have called attention to a possible way by which cancer cells can evade death and become resistant to treatments (discussed in Erenpreisa et al., 2008; Wheatley, 2008). Some cancer cells duplicate chromosomes inside their nucleus without undergoing mitosis. The resultant large polyploid cells remain quiescent, but eventually a small percentage undergoes reduction divisions to form diploid or pseudo-diploid cells which then proliferate via normal mitosis, and which sometimes are more resistant to treatment than were the original cells (e.g., Puig et al., 2008). However, this is not a specific trait of cancer cells because somatic reduction divisions regularly occur in non-cancerous cells, the best-studied example being cells of the mosquito gut.enWiley This is the peer reviewed version of the following article: [Cell Biology International 33.2 (2009) 253-253], which has been published in final form at [https://doi.org/10.1016/j.cellbi.2008.11.004]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.Attribution-NoDerivatives 4.0 InternationalArticlehttps://onlinelibrary.wiley.com/toc/10958355/2009/33/2https://onlinelibrary.wiley.com/https://onlinelibrary.wiley.com/doi/abs/10.1016/j.cellbi.2008.11.004