Magierowski, SebastianGhafar-Zadeh, Ebrahim2017-07-272017-07-272016-12-062017-07-27http://hdl.handle.net/10315/33468DNA sequencing is undergoing a profound evolution into a mobile technology. Unfortunately the effort needed to process the data emerging from this new sequencing technology requires a compute power only available to traditional desktop or cloud-based machines. To empower the full potential of portable DNA solutions a means of efficiently carrying out their computing needs in an embedded format will certainly be required. This thesis presents the design of a custom fixed-point VLSI hardware implementation of an HMM-based multi-channel DNA sequence processor. A 4096 state (6-mer nanopore sensor) basecalling architecture is designed in a 32-nm CMOS technology with the ability to process 1 million DNA base pairs per second per channel. Over a 100 mm^2 silicon footprint the design could process the equivalent of one human genome every 30 seconds at a power consumption of around 5 W.enAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.BioinformaticsElectronic Thesis or Dissertation2017-07-27NanoporeASICInformation processingBasecallingBasecallerFixed-pointMulti-channel