Wong, NikitaRafique, SaraMoro, Stefania S.Kelly, KristaSteeves, Jennifer2020-02-282020-02-282019Altered white matter structure in auditory tracts following early monocular enucleation Wong, N.A., Rafique, S.A., Moro, S.S., Kelly, K.R. and Steeves, J.K.E. NeuroImage: Clinical • 2019https://doi.org/10.1016/j.nicl.2019.102006https://hdl.handle.net/10315/37025Purpose: Similar to early blindness, monocular enucleation (the removal of one eye) early in life results in crossmodal behavioral and morphological adaptations. Previously it has been shown that partial visual deprivation from early monocular enucleation results in structural white matter changes throughout the visual system (Wong et al., 2018). The current study investigated structural white matter of the auditory system in adults who have undergone early monocular enucleation compared to binocular control participants. Methods: We reconstructed four auditory and audiovisual tracts of interest using probabilistic tractography and compared microstructural properties of these tracts to binocularly intact controls using standard diffusion indices. Results: Although both groups demonstrated asymmetries in indices in intrahemispheric tracts, monocular enucleation participants showed asymmetries opposite to control participants in the auditory and A1-V1 tracts. Monocularenucleation participants also demonstrated significantly lower fractional anisotropy in the audiovisual projections contralateral to the enucleated eye relative to control participants. Conclusions: Partial vision loss from early monocular enucleation results in altered structuralenAttribution-NonCommercial-NoDerivs 2.5 CanadaArticlehttps://www.sciencedirect.com/journal/neuroimage-clinicalhttps://www.elsevier.com/https://www.sciencedirect.com/science/article/pii/S2213158219303560