Snijdelaar, Dirk G.Cornelisse, H.B.Schmid, R. L.Katz, Joel2011-05-182011-05-182004Anaesthesia, 59(3), 222-228. (2004)http://hdl.handle.net/10315/7962In a randomised, double-blind prospective study we compared the effects on postoperative pain and analgesic consumption of intra-operative s(+)-ketamine (100 μg.kg−1 bolus and a continuous infusion of 2 μg.kg−1.min−1) followed by postoperative patient-controlled analgesia with morphine (1 mg per bolus) plus s(+)-ketamine (0.5 mg per bolus), or intra-operative saline followed by postoperative patient-controlled analgesia morphine (1 mg per bolus) alone. A total of 28 male patients undergoing radical prostatectomy were studied. Morphine consumption, pain scores, pressure algometry and adverse effects were recorded for 48 h after surgery. Cumulative morphine consumption was significantly lower in the ketamine/morphine group (47.9 ± 26.2 mg) than in the saline/morphine group (73.4 ± 34.8 mg; p = 0.049). Pain scores at rest were significantly lower in the ketamine/morphine group across the 48-h study period (p = 0.01). No significant differences were found in pressure algometry measurements or the occurrence of adverse effects.enArticlehttp://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2044http://www.lww.com/http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2044.2003.03620.x/pdf